2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W753593
    N4-Acetylcytidine-13C5
    N4-Acetylcytidine-13C5 is the 13C-labeled N4-Acetylcytidine (HY-W019670). N4-acetylcytidine (N4A) is an endogenous nucleoside metabolite from the degradation of tRNA. N4-Acetylcytidine is formed by N-acetyltransferase 10 and other enzymes. N4-acetylcytidine might sustain NLRP3 inflammasome activation via induction of HMGB1 expression and releasee. N4-Acetylcytidine modifies mRNA, tRNA and rRNA, affecting their stability, translation efficiency (such as enterovirus 71 RNA). N4-Acetylcytidine is used in the study of cancer, neuroinflammatory diseases, viral infections and obesity.
    N4-Acetylcytidine-13C5
  • HY-W760733
    2,4-Decadienal 2363-88-4
    2,4-Decadienal is a toxic aldehyde produced by the oxidation of linoleic acid-rich oils. 2,4-decadienal can be used as an alternative oxidation indicator for linoleic acid-rich oils.
    2,4-Decadienal
  • HY-W983015
    Davidigenin 23130-26-9 98.13%
    Davidigenin is an antidiabetic compound with antitumor, antispasmodic, and antioxidant activities. Davidigenin inhibits duodenal contractions induced by acetylcholine or histamine.
    Davidigenin
  • HY-100442S1
    Paquinimod-d5-1 98.19%
    Paquinimod-d5-1 is a deuterated analog of Paquinimod (HY-100442). Paquinimod (ABR 215757) is a specific and orally active inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice.
    Paquinimod-d5-1
  • HY-101400S3
    Deoxycytidine triphosphate-15N3 dilithium 99.0%
    Deoxycytidine triphosphate-15N3 (dCTP-15N3 dilithium; 2′-Deoxycytidine-5′-triphosphate-15N3) dilithium is 15N labeled Deoxycytidine triphosphate (HY-101400). Deoxycytidine triphosphate (dCTP) is a nucleoside triphosphate that can be used for DNA synthesis. Deoxycytidine triphosphate has many applications, such as real-time PCR, cDNA synthesis, and DNA sequencing.
    Deoxycytidine triphosphate-15N3 dilithium
  • HY-113031S1
    16α-Hydroxydehydroepiandrosterone-d5
    16α-Hydroxydehydroepiandrosterone-d5 (16α-Hydroxy-DHEA-d5) is the deuterium labeled 16α-Hydroxydehydroepiandrosterone (HY-113031).
    16α-Hydroxydehydroepiandrosterone-d5
  • HY-113416AS
    Dehydroepiandrosterone sulfate-d6 sodium dihydrate ≥98.0%
    Dehydroepiandrosterone sulfate sodium dihydrate-d6 sodium dihydrate is the deuterium labeled Dehydroepiandrosterone sulfate sodium dihydrate. Dehydroepiandrosterone sulfate (DHEA sulfate; Prasterone sulfate) sodium dihydrate is a neurosteroid and the main secretion product of the adrenal gland. Dehydroepiandrosterone sulfate sodium dihydrate has both non-competitive antagonist activity of GABAA receptor and agonist activity of σ1 receptor. Dehydroepiandrosterone sulfate sodium dihydrate can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid and antidepressant effects, and increase convulsive sensitivity. Dehydroepiandrosterone sulfate sodium dihydrate participates in neuroprotection, neurite growth regulation and catecholamine secretion regulation, and can be used in the study of depression, post-traumatic stress disorder (PTSD), Alzheimer's disease, etc. Dehydroepiandrosterone sulfate sodium dihydrate may also be a biomarker for cardiovascular disease mortality, and its concentration is independently and negatively correlated with mortality.
    Dehydroepiandrosterone sulfate-d6 sodium dihydrate
  • HY-124177AS
    C14 Ceramide (d18:1/14:0)-d7 99.35%
    C14 Ceramide (d18:1/14:0)-d7 is the deuterium labeled C14 Ceramide (d18:1/14:0) (HY-124177A). C14 Ceramide (d18:1/14:0) is an endogenous ceramide produced by ceramide synthetase 6, which can be used for Parkinson's and diabetes research.
    C14 Ceramide (d18:1/14:0)-d7
  • HY-B0389S24
    D-Glucose-d4 478529-49-6 99.0%
    D-Glucose-d4 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molec
    D-Glucose-d4
  • HY-B0389S29
    D-Glucose-18O 3343-70-2 99.9%
    D-Glucose-18O is the 18O labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules
    D-Glucose-18O
  • HY-N0215S14
    L-Phenylalanine-15N,d8 99.90%
    L-Phenylalanine-15N,d8 is the deuterium and 15N-labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated from Escherichia coli. L-Phenylalanine is a α2δ subunit of voltage-dependent Ca2+ channels antagonist with a Ki of 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites of N-methyl-D-aspartate receptors (NMDARs) (KB of 573 μM ) and non-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals.
    L-Phenylalanine-15N,d8
  • HY-N0390S10
    L-Glutamine-1,2-13C2 98.0%
    L-Glutamine-1,2-13C2 is the 13C-labeled L-Glutamine. L-Glutamine (L-Glutamic acid 5-amide) is a non-essential amino acid present abundantly throughout the body and involved in many metabolic processes. L-Glutamine provides a source of carbons for oxidation in some cells.
    L-Glutamine-1,2-13C2
  • HY-N0486S10
    L-Leucine-18O2 73579-45-0 98%
    L-Leucine-18O2 is the 18O-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
    L-Leucine-18O2
  • HY-N0486S12
    L-Leucine-d2 362049-59-0 99.81%
    L-Leucine-d2 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
    L-Leucine-d2
  • HY-W001909S
    Myosmine-d4 66148-17-2 99.25%
    Myosmine-d4 is the deuterium labeled Myosmine. Myosmine, a specific tobacco alkaloid in nuts and nut products, has low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a Ki of 3300 nM.
    Myosmine-d4
  • HY-W008151S
    Diphenyl Phosphate-d10 1477494-97-5 99.74%
    Diphenyl Phosphate-d10 (DPhP-d10) is the deuterium labled Diphenyl Phosphate (HY-W008151). Diphenyl Phosphate inhibits growth and energy metabolism of zebrafish in a sex-specific manner.
    Diphenyl Phosphate-d10
  • HY-W009216S
    2'-Deoxycytidine-5'-monophosphate-15N3 98.76%
    2'-Deoxycytidine-5'-monophosphoric acid-15N3 is the 15N labeled 2'-Deoxycytidine-5'-monophosphoric acid. 2'-Deoxycytidine-5'-monophosphoric acid is an endogenous metabolite.
    2'-Deoxycytidine-5'-monophosphate-15N3
  • HY-W010248S
    2-Phenylglycine-d5 358731-96-1 99.01%
    2-Phenylglycine-d5 is the deuterium labeled 2-Phenylglycine. 2-Phenylglycine (DL-α-Phenylglycine) is a metabolite in breast milk during the W2 to W4 lactation period.
    2-Phenylglycine-d5
  • HY-W010255S
    Phenylglyoxylic acid-d5 1217089-53-6 99.82%
    Phenylglyoxylic acid-d5 (Benzoylformic acid-d5) is a deuterium labeled Phenylglyoxylic acid (HY-W010255). Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human. Phenylglyoxylic acid can be used as drug intermediate for synthesis of antineoplastic compounds.
    Phenylglyoxylic acid-d5
  • HY-W011704A
    Phosphoenolpyruvic acid tricyclohexylammoniu​m salt 35556-70-8 99.66%
    Phosphoenolpyruvic acid (Phosphoenolpyruvate) tricyclohexylammoniu​m salt is a glycolysis metabolite with a high-energy phosphate group. Phosphoenolpyruvic acid tricyclohexylammoniu​m salt is involved in glycolysis and gluconeogenesis, and used as energy source to produce ATP, under the energy-limited conditions. Phosphoenolpyruvic acid tricyclohexylammoniu​m salt also exhibits cytoprotective and anti-oxidative properties.
    Phosphoenolpyruvic acid tricyclohexylammoniu​m salt
Cat. No. Product Name / Synonyms Application Reactivity